This paper assesses the accuracy of fatigue crack growth (FCG) predictions for high-strength aluminum samples containing residual stress (RS) and complex two-dimensional cracks subjected to constant amplitude load. FCG predictions use linear-elastic, multi-point fracture mechanics. A first prediction includes RS estimated by the model described in Part 1; a second prediction includes RS measured by the contour method. FCG test data show a significant influence of RS. Ignoring the RS results in a +60% error in predicted FCG life (non-conservative). Including RS improves predictions of crack growth significantly (errors better than +26% (estimated RS) and -14% (measured RS)).